{
    "query": "28",
    "resultCount": 6,
    "source": "kingbrand.com\/Studies.php",
    "results": [
        {
            "studyNumber": 9,
            "shortTitle": "Shortwave and Microwave Diathermy for Nerve Regeneration",
            "fullTitle": "Role of Shortwave and Microwave Diathermy in Peripheral Neuropathy",
            "authors": "T. Fu, W.C. Lineaweaver, F. Zhang, J. Zhang",
            "journal": "Journal of International Medical Research (2019)",
            "summary": "This review analyzed the effects of shortwave and microwave diathermy on nerve regeneration in both animal models and human patients. Animal studies showed that diathermy improved nerve healing by increasing the number of myelinated fibers, myelin sheath thickness, and axon diameter, leading to better nerve function. In clinical studies involving 128 patients with carpal tunnel syndrome, diathermy was associated with reduced pain, improved hand function, and better electrophysiological outcomes. These findings suggest that shortwave and microwave diathermy may be beneficial for peripheral nerve repair.",
            "pubmedUrl": "https:\/\/pubmed.ncbi.nlm.nih.gov\/31304815\/"
        },
        {
            "studyNumber": 34,
            "shortTitle": "Risk Factors Affecting Chronic Rupture of the Plantar Fascia",
            "fullTitle": "Risk factors affecting chronic rupture of the plantar fascia",
            "authors": "Ho Seong Lee, Young Rak Choi, Sang Woo Kim, Jin Yong Lee, Jeong Ho Seo, Jae Jung Jeong",
            "journal": "Foot & Ankle International (2014)",
            "summary": "This retrospective comparative study analyzed 286 patients with plantar fasciitis to identify risk factors associated with chronic rupture of the plantar fascia. Among the 35 patients who experienced a rupture, 33 had received corticosteroid injections, indicating a strong association between steroid use and rupture risk. The study concluded that corticosteroid injections should be administered cautiously due to the significantly higher risk of plantar fascia rupture.",
            "pubmedUrl": "https:\/\/pubmed.ncbi.nlm.nih.gov\/24275488\/"
        },
        {
            "studyNumber": 77,
            "shortTitle": "Nearly Half of Acetaminophen Liver Failure Cases Are Unintentional Overdoses",
            "fullTitle": "Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study.",
            "authors": "Larson AM, Polson J, Fontana RJ, Davern TJ, Lalani E, Hynan LS, et al.",
            "journal": "Hepatology (2005)",
            "summary": "This prospective multicenter study tracked 662 patients with acute liver failure across 22 tertiary care centers in the United States over 6 years. Of these, 275 cases (42%) were caused by acetaminophen liver injury. The percentage of acetaminophen-related liver failure rose from 28% in 1998 to 51% in 2003. Critically, 48% of these cases were unintentional overdoses, not suicide attempts. The median dose ingested was 24 grams (equivalent to 48 extra-strength tablets). Among unintentional overdose patients, 38% had taken two or more acetaminophen products simultaneously, and 81% reported using acetaminophen for acute or chronic pain syndromes. Overall, 27% of patients died without transplantation and 8% required liver transplants. The study demonstrates that the majority of acetaminophen-induced liver failure is not from intentional self-harm but from people taking too much acetaminophen over time while trying to manage pain. Patients with chronic pain conditions who use acetaminophen for extended periods are particularly vulnerable, as they may unknowingly exceed safe dosing limits by combining multiple products or taking doses that accumulate to toxic levels. These findings support the recommendation that pain relievers should not be relied upon as a long-term strategy for managing soft tissue injuries.",
            "pubmedUrl": "https:\/\/pubmed.ncbi.nlm.nih.gov\/16317692\/"
        },
        {
            "studyNumber": 78,
            "shortTitle": "NSAIDs Significantly Increase Risk of Gastrointestinal Bleeding",
            "fullTitle": "Individual NSAIDs and upper gastrointestinal complications: a systematic review and meta-analysis of observational studies (the SOS project).",
            "authors": "Castellsague J, Riera-Guardia N, Calingaert B, Varas-Lorenzo C, Fourrier-Reglat A, Nicotra F, et al.",
            "journal": "Drug Safety (2012)",
            "summary": "This systematic review and meta-analysis analyzed 28 observational studies to evaluate the risk of upper gastrointestinal complications associated with individual NSAIDs. The study found that all NSAIDs carry a risk of serious GI complications including bleeding, perforation, and obstruction, but the risk varies significantly between specific drugs. Ibuprofen had a relative risk of 1.84 compared to non-use, while naproxen carried a relative risk of 4.10. Other commonly used NSAIDs showed even higher risks, with piroxicam at 7.43 and ketorolac at 11.50. Importantly, the study found that high daily doses of NSAIDs carried 2 to 3 times greater risk than low daily doses, confirming that both the dose and duration of NSAID use directly affect the likelihood of gastrointestinal injury. The researchers analyzed data from studies covering clinical practice settings, making the findings applicable to real-world use. These results support the recommendation that NSAIDs should be used at the lowest effective dose for the shortest possible duration, taken with food, and timed to avoid periods of activity where pain masking could lead to reinjury. The dose-dependent nature of the risk reinforces the guidance that extended, around-the-clock NSAID use carries significant cumulative danger to the gastrointestinal system.",
            "pubmedUrl": "https:\/\/pubmed.ncbi.nlm.nih.gov\/23137151\/"
        },
        {
            "studyNumber": 87,
            "shortTitle": "Over-the-Counter NSAIDs Carry Significant Gastrointestinal Risk",
            "fullTitle": "Risk of serious upper gastrointestinal toxicity with over-the-counter nonaspirin nonsteroidal anti-inflammatory drugs.",
            "authors": "Lewis JD, Kimmel SE, Localio AR, Metz DC, Farrar JT, Nessel L, et al.",
            "journal": "Gastroenterology (2005)",
            "summary": "This study assessed the risk of serious upper gastrointestinal toxicity from over-the-counter (OTC) non-aspirin NSAIDs such as ibuprofen and naproxen. The researchers recruited 359 patients hospitalized for upper gastrointestinal bleeding, perforation, or benign gastric outlet obstruction from 28 hospitals, along with 1,889 control subjects. The study found that OTC NSAID use was associated with a significantly increased risk of serious upper gastrointestinal complications. Even though OTC NSAIDs are typically used at lower doses and for shorter durations than prescription NSAIDs, they still carried meaningful risk. The risk increased with higher doses and longer duration of use. Importantly, many patients who experienced GI complications had been using OTC NSAIDs at doses that are commonly considered safe for self-medication. The study also found that the risk was elevated even with short-term use in some cases, particularly when multiple doses were taken throughout the day. These findings are particularly relevant for individuals managing soft tissue injuries, who may take OTC pain relievers for extended periods while recovering. The results support the recommendation that even over-the-counter NSAIDs should be used judiciously, taken with food, limited to the lowest effective dose, and timed to avoid periods of activity where pain masking could lead to reinjury.",
            "pubmedUrl": "https:\/\/pubmed.ncbi.nlm.nih.gov\/16344055\/"
        },
        {
            "studyNumber": 92,
            "shortTitle": "Topical NSAIDs Are Effective for Tennis Elbow Without Oral Side Effects",
            "fullTitle": "Non-steroidal anti-inflammatory drugs (NSAIDs) for treating lateral elbow pain in adults.",
            "authors": "Pattanittum P, Turner T, Green S, Buchbinder R",
            "journal": "Cochrane Database of Systematic Reviews (2013)",
            "summary": "This Cochrane systematic review analyzed 15 trials with 759 participants to evaluate the effectiveness of topical and oral NSAIDs for treating lateral elbow pain, commonly known as tennis elbow. The review found that topical NSAIDs were significantly more effective than placebo for short-term pain relief, with a number needed to treat of 7, meaning that for every 7 patients treated with topical NSAIDs, one additional patient experienced significant pain relief compared to placebo. Participants using topical NSAIDs also reported better overall treatment effectiveness at 28 days. Adverse effects from topical NSAIDs were minimal, with only mild skin reactions such as rash reported in 2.5% of users, compared to 1.3% with placebo. For oral NSAIDs, the evidence was conflicting. One trial found significant pain improvement compared to placebo while another found no difference, and neither showed improvement in function. Notably, oral NSAIDs were associated with an increased risk of gastrointestinal side effects, and several participants had to discontinue treatment due to GI issues. The review found no trials that directly compared topical and oral NSAIDs head to head. These findings support the use of topical NSAIDs as a first-line option for conditions like tennis elbow, where the anti-inflammatory medication can be delivered directly to the injured tendon without exposing the gastrointestinal system to the risks associated with oral NSAIDs. For patients who do use oral NSAIDs, the evidence suggests limiting duration to the short term.",
            "pubmedUrl": "https:\/\/pubmed.ncbi.nlm.nih.gov\/23728646\/"
        }
    ]
}