{
    "query": "60",
    "resultCount": 5,
    "source": "kingbrand.com\/Studies.php",
    "results": [
        {
            "studyNumber": 88,
            "shortTitle": "Ibuprofen 400 mg Is as Effective as Higher Doses for Pain Relief",
            "fullTitle": "Analgesic effect of oral ibuprofen 400, 600, and 800 mg; paracetamol 500 and 1000 mg; and paracetamol 1000 mg plus 60 mg codeine in acute postoperative pain: a single-dose, randomized, placebo-controlled, and double-blind study.",
            "authors": "Lyngstad G, Skjelbred P, Swanson DM, Skoglund LA",
            "journal": "European Journal of Clinical Pharmacology (2021)",
            "summary": "This randomized, double-blind, placebo-controlled study compared the pain-relieving effectiveness of different doses of ibuprofen and other common pain medications in 350 patients after third molar surgery. Patients received either ibuprofen at 400 mg, 600 mg, or 800 mg, paracetamol at 500 mg or 1000 mg, a paracetamol-codeine combination, or a placebo. The researchers measured pain intensity over 6 hours, time to pain relief, duration of effectiveness, and the number of patients needing additional medication. The key finding was that ibuprofen doses above 400 mg did not significantly increase pain relief. In other words, taking 600 mg or 800 mg of ibuprofen provides essentially the same benefit as taking 400 mg, but with a higher dose that increases the risk of side effects. All active ibuprofen doses were similarly effective, and adverse effects were low and mild across all groups. This study directly supports the recommendation that 400 mg of ibuprofen is a sufficient dose for effective pain and inflammation relief. Taking more does not provide additional benefit but does increase exposure and risk, particularly to the gastrointestinal system. This finding validates a low-dose strategy that maximizes therapeutic benefit while minimizing the potential for harm.",
            "pubmedUrl": "https:\/\/pubmed.ncbi.nlm.nih.gov\/34655316\/"
        },
        {
            "studyNumber": 4,
            "shortTitle": "Effects of Far-Infrared Radiation Lamp Therapy on Recovery from Muscle Damage",
            "fullTitle": "Effects of Far-Infrared Radiation Lamp Therapy on Recovery from Muscle Damage Induced by Eccentric Exercise",
            "authors": "Trevor C. Chen, Yuh-Chuan Huang, Tai-Ying Chou, Sheng-Tsung Hsu, Mei-Yen Chen, Kazunori Nosaka",
            "journal": "European Journal of Sport Science (2023)",
            "summary": "This study examined the effects of far-infrared radiation (FIR) lamp therapy on muscle damage and proprioception following eccentric exercise of the elbow and knee flexors. In a controlled experiment, 24 sedentary women received either FIR therapy or a sham treatment. The FIR group showed significantly faster recovery in muscle strength and proprioception, reduced muscle soreness by 55-60%, and lowered peak plasma creatine kinase activity by 45-89%. FIR therapy accelerated recovery from exercise-induced muscle damage more effectively than previously studied interventions.",
            "pubmedUrl": "https:\/\/pubmed.ncbi.nlm.nih.gov\/36825876\/"
        },
        {
            "studyNumber": 10,
            "shortTitle": "Effects of Heat, Cold, and Pressure on the Transverse Carpal Ligament and Median Nerve",
            "fullTitle": "Effect of Heat, Cold, and Pressure on the Transverse Carpal Ligament and Median Nerve: A Pilot Study",
            "authors": "Michael Laymon, Jerrold Petrofsky, James McKivigan, Haneul Lee, JongEun Yim",
            "journal": "Medical Science Monitor (2015)",
            "summary": "This pilot study investigated the effects of heat, cold, and pressure on the median nerve and transverse carpal ligament in healthy individuals. Using ultrasound imaging, researchers assessed ligament elasticity, nerve conduction velocity, and structural changes. Heat therapy (60-120 minutes) increased ligament and tendon elasticity, while cold exposure (20 minutes) reduced compression of the carpal ligament and nerve. Pressure did not significantly alter tissue structure at room temperature or after cold exposure. The findings suggest that heat enhances tissue flexibility, whereas cold may help reduce compression in conditions like carpal tunnel syndrome.",
            "pubmedUrl": "https:\/\/pubmed.ncbi.nlm.nih.gov\/25669437\/"
        },
        {
            "studyNumber": 12,
            "shortTitle": "Shortwave Diathermy Enhances Recovery in Lateral Epicondylitis",
            "fullTitle": "Continuous Shortwave Diathermy with Exercise Reduces Pain and Improves Function in Lateral Epicondylitis More Than Sham Diathermy: A Randomized Controlled Trial",
            "authors": "A. Babaei-Ghazani, B. Shahrami, E. Fallah, T. Ahadi, B. Forough, S. Ebadi",
            "journal": "Journal of Bodywork & Movement Therapies (2020)",
            "summary": "This study evaluated the effectiveness of continuous shortwave diathermy (SWD) in treating chronic lateral epicondylitis (tennis elbow). Fifty patients were assigned to either an SWD + exercise group or a sham diathermy + exercise group. The SWD group received 15 minutes of 40-60 W continuous SWD along with specific exercises. Pain, function, and grip strength were measured at baseline, after 5 and 10 treatment sessions, and at 3 months. The SWD group showed significantly greater improvements in all outcomes compared to the control group. These findings suggest that SWD enhances pain relief and functional recovery in lateral epicondylitis.",
            "pubmedUrl": "https:\/\/pubmed.ncbi.nlm.nih.gov\/31987565\/"
        },
        {
            "studyNumber": 76,
            "shortTitle": "Acetaminophen Is the Leading Cause of Acute Liver Failure in the United States",
            "fullTitle": "Acetaminophen and the U.S. Acute Liver Failure Study Group: lowering the risks of hepatic failure.",
            "authors": "Lee WM",
            "journal": "Hepatology (2004)",
            "summary": "This review examined data from the U.S. Acute Liver Failure Study Group, a registry of over 700 patients with acute liver failure across the United States. The findings reveal that acetaminophen (Tylenol) overdose is the leading cause of calls to Poison Control Centers, accounting for more than 100,000 calls per year. It is responsible for more than 56,000 emergency room visits, 2,600 hospitalizations, and an estimated 458 deaths due to acute liver failure annually. Acetaminophen poisoning was implicated in nearly 50% of all acute liver failure cases in the country. The study highlights that while acetaminophen is heavily marketed for its safety compared to NSAIDs and is readily available over the counter, the scale of injury and death associated with its misuse is substantial. The author questions whether this level of harm is acceptable for an over-the-counter pain reliever, particularly when unintentional overdosing occurs from taking multiple acetaminophen-containing products simultaneously or using them for extended periods. The findings support caution with acetaminophen use, especially for chronic pain conditions that may lead to prolonged or excessive consumption.",
            "pubmedUrl": "https:\/\/pubmed.ncbi.nlm.nih.gov\/15239078\/"
        }
    ]
}