{
    "query": "meniscus",
    "resultCount": 3,
    "source": "kingbrand.com\/Studies.php",
    "results": [
        {
            "studyNumber": 29,
            "shortTitle": "Surgery Does Not Improve Long-Term Outcomes in Degenerative Meniscus Tears",
            "fullTitle": "Arthroscopic partial meniscectomy for a degenerative meniscus tear: a 5 year follow-up of the placebo-surgery controlled FIDELITY trial",
            "authors": "Raine Sihvonen, Mika Paavola, Antti Malmivaara, Ari Itälä, Antti Joukainen, Juha Kalske, Heikki Nurmi, Jaanika Kumm, Niko Sillanpää, Tommi Kiekara, Aleksandra Turkiewicz, Pirjo Toivonen, Martin Englund, Simo Taimela, Teppo L N Järvinen",
            "journal": "British Journal of Sports Medicine (2020)",
            "summary": "This 5-year follow-up of the FIDELITY randomized, placebo-surgery controlled trial assessed the long-term effects of arthroscopic partial meniscectomy (APM) in 146 adults with degenerative medial meniscus tears. Compared to placebo surgery, APM showed no benefit in knee symptoms, function, or pain reduction, but was associated with a slightly higher risk of radiographic knee osteoarthritis. The findings suggest that APM does not offer long-term advantages and may accelerate joint degeneration in this population.",
            "pubmedUrl": "https:\/\/pubmed.ncbi.nlm.nih.gov\/32855201\/"
        },
        {
            "studyNumber": 28,
            "shortTitle": "Meniscectomy Often No Better Than Conservative Treatment",
            "fullTitle": "A comparative study of meniscectomy and nonoperative treatment for degenerative horizontal tears of the medial meniscus",
            "authors": "Ji-Hyeon Yim, Jong-Keun Seon, Eun-Kyoo Song, Jun-Ik Choi, Min-Cheol Kim, Keun-Bae Lee, Hyoung-Yeon Seo",
            "journal": "American Journal of Sports Medicine (2013)",
            "summary": "This randomized controlled trial compared outcomes of arthroscopic meniscectomy versus nonoperative treatment with strengthening exercises in 102 patients with degenerative horizontal medial meniscus tears. After 2 years, there were no significant differences in pain relief, knee function, or patient satisfaction between the two groups. The findings support the use of conservative treatment as a viable alternative to surgery in many cases.",
            "pubmedUrl": "https:\/\/pubmed.ncbi.nlm.nih.gov\/23703915\/"
        },
        {
            "studyNumber": 79,
            "shortTitle": "COX-2 Inhibitors Impair Soft Tissue Healing While Nonselective NSAIDs May Not",
            "fullTitle": "Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) and Their Effect on Musculoskeletal Soft-Tissue Healing: A Scoping Review.",
            "authors": "Ghosh N, Kolade OO, Shontz E, Rosenthal Y, Zuckerman JD, Bosco JA, et al.",
            "journal": "JBJS Reviews (2019)",
            "summary": "This scoping review examined 44 studies to evaluate the effects of NSAIDs on the healing of musculoskeletal soft tissues including ligaments, tendons, labrum, and meniscus. The findings reveal an important distinction between types of NSAIDs. The majority of studies, including 1 of 2 human studies, 10 of 14 animal studies, and 3 of 3 in vitro studies, demonstrated that COX-2-selective inhibitors (such as celecoxib) had a negative impact on soft tissue healing. In contrast, the majority of studies showed that nonselective COX inhibitors (such as ibuprofen) had no negative effect on the healing of labrum, tendons, and ligaments. In vitro studies showed that NSAIDs generally have a harmful effect on the biological processes involved in tendon healing, including tenocyte proliferation and collagen synthesis. This study supports the nuanced position that not all NSAIDs affect healing equally. The anti-inflammatory properties of nonselective NSAIDs may benefit conditions involving tendons, ligaments, and cartilage where inflammation increases reinjury risk, while COX-2 selective inhibitors should be avoided during healing. These findings highlight the importance of understanding which specific medication a patient is taking and how it may interact with their recovery from a soft tissue injury.",
            "pubmedUrl": "https:\/\/pubmed.ncbi.nlm.nih.gov\/31851037\/"
        }
    ]
}