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Local and Systemic Side Effects of Corticosteroid Injections for Musculoskeletal Indications

AJR American Journal of Roentgenology (2024) · Sarah I. Kamel, Humberto G. Rosas, Tetyana Gorbachova

Full Title

Local and Systemic Side Effects of Corticosteroid Injections for Musculoskeletal Indications

Summary

This comprehensive review outlines both local and systemic adverse effects associated with corticosteroid injections used for musculoskeletal conditions. Local side effects include post-injection flare, skin hypopigmentation and atrophy, infection, tendon rupture, accelerated progression of osteoarthritis, and osseous injury. Systemic side effects encompass adrenal suppression or insufficiency, facial flushing, hypertension, hyperglycemia, and osteoporosis. The authors emphasize the importance of recognizing these potential side effects when counseling patients and planning individual injections. The review highlights the need for further research regarding the long-term complications of continuous corticosteroid use, particularly concerning osseous effects.

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